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Literature summary extracted from

  • Buehling, F.; Kouadio, M.; Chwieralski, C.E.; Kern, U.; Hohlfeld, J.M.; Klemm, N.; Friedrichs, N.; Roth, W.; Deussing, J.M.; Peters, C.; Reinheckel, T.
    Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice (2011), PLoS ONE, 6, e26247.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.16 25000
-
 x * 25000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.16 surfactant protein B + H2O Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.16 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.16 kidney highest activity is detected in the kidney Mus musculus
-
3.4.22.16 liver
-
 Mus musculus
-
3.4.22.16 lung
-
 Mus musculus
-
3.4.22.16 pneumocyte cathepsin H is highly expressed in the secretory organelles of alveolar type II pneumocytes Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.16 L-Arg-7-amido-4-methylcoumarin + H2O specific substrate Mus musculus L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.16 surfactant protein B + H2O
-
 Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.16 ? x * 25000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.22.16 CTSH
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.22.16 malfunction cathepsin H-deficient mice show no gross phenotype and their development is normal without growth retardation. Broncho-alveolar lavage from cathepsin H-deficient mice contain lower levels of pulmonary surfactant protein B Mus musculus
3.4.22.16 physiological function cathepsin H is involved in the surfactant protein B production Mus musculus